Question
Define oxygen dissociation curve. Can you suggest any reason for its sigmoidal pattern?
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Answer
- The oxygen dissociation curve is a graph obtained when the percentage saturation of haemoglobin with oxygen is plotted against the partial pressure of oxygen.
- When the first molecule of oxygen binds to haemoglobin, its affinity for the second molecule of oxygen increases.
- Hence, the formation of oxyhaemoglobin is faster which is indicated by the steep slope of the S curve.
- When the formation of oxyhaemoglobin comes to rest or when there are no haemoglobin molecules available for binding, the curve achieves a plateau phase.
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