MCQ
Mutation was first discovered by:
- AMuller
- BMorgan
- CStadler
- DHugo de Vries
Explanation:
Thomas Hunt Morgan discovered mutation of white-eyed in fruitfly and was awarded Noble prize for this in 1933. Normally these flies have red colour eyes but he noticed that few male flies have white colour eyes. He immediately crossed these flies with wild flies i.e., red-eyed flies and observed that the F1 generation has only red-eyed flies but when he selfed these flies he saw the ratio is 3 : 1.
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$I$. In the absence of adenosine deaminase enzyme, purine metabolism is disturbed and $T-$lymphocytes fails to function $II$. $ADA$ deficiency is caused by the deletion of the gene for $ADA$
$III$. In some cases, it can be cured by bone marrow transplantation and enzyme replacement therapy. But in both approaches, the patients are not completely cured
$IV$. For permanent cure, genes isolated from the bone marrow cells producing $ADA$ at early embryonic stages can be a possible cure
Which of the above statements are correct?