Sickle cell anaemia is

MCQ

A
An autosomal linked dominant trait
✓
Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin
C
Caused by a change in $3$ base pairs of $DNA$
D
Characterized by elongated sickle like $RBCs$ with a nucleus

✓

Answer

Correct option: B.

Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin

b
Sickle cell anaemia is caused by a change in a single base pair of DNA. It is an autosomal recessive genetic disease reported from Negroes. In sickle cell haemoglobin the glutamic acid in beta haemoglobin chain is replaced by valine.

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