MCQ
Sickle cell anemia is caused by:
- AComplete absence of the haemoglobin gene
- BPoint mutation of the haemoglobin gene
- CIncreased affinity of haemoglobin for oxygen
- DTruncation of the haemoglobin protein
Explanation:
Hemoglobin has four protein subunits, two α-globin and two β - globin. The Hbb gene codes the β chain. A missense mutation, replacement of A by T at the 17th nucleotide of the Hbb gene changes the codon GAG (glutamic acid) to GTG (which encodes valine).
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| Column $- I$ | Column $- II$ |
| $(a)$ Parturition | $(p)$ Attachment of embryo to endometrium |
| $(b)$ Gestation | $(q)$ Release of egg from Graafian follicle |
| $(c)$ Ovulation | $(r)$ Delivery of Foetus from uterus |
| $(d)$ Implantation | $(s)$ Duration between pregnancy and birth |
| $(t)$ Formation of zygote by fusion of egg and sperm |