The binding of oxygen by haemoglobin $(Hb)$ forming $(HbO_2)$, is partially regulated by the concentration of $H_3O^+$ and dissolved $CO_2$ in blood.
$Hb{O_2} + {H_3}{O^ + }C{O_2} \rightleftharpoons \left( {{H^ + } - Hb - C{O_2}} \right) + {O_2} + {H_2}O$
Release of $O_2$ is favoured when there is
Difficult
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