Question
The main responsible factor for depletion of ozone layer is CFC.

Answer

The ozone layer in stratosphere absorbs harmful ultraviolet radiation from the sunlight and prevents it from reaching the earth.
CFC (Chlorofluorocarbon) adds chlorine (Cl-) in atmosphere. The chlorine atom reacts with ozone and removes an atom of oxygen one by one. One atom of chlorine can decompose many molecules of ozone in this fashion. CFC thus causes about 80% of the total depletion of ozone.
Thus, the main responsible factor for depletion of ozone layer is CFC.

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