Why does the platelet count decrease in dengue patient?

Question

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Answer

The causative pathogen of dengue is dengue virus which induces bone marrow suppression. Since in bone marrow blood cells are formed its suppression causes the deficiency of blood cells leading to low platelet count.
The dengue virus also links with platelets in the blood when there is a virus-specific antibody present in the human body.
When vascular endothelial cell which are infected with dengue virus gets combined with platelets, they tend to destroy platelets. This is one of the major causes of low platelet count in dengue fever.
Even the antibodies that are produced after infection of the dengue virus also cause the destruction of platelets, thus lowering the platelet count.

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(i) Severo Ochoa
(ii) F. Jacob and J. Monod
(iii) Temin and Baltimore
(iv) H. Winkler
(v) T. H. Roderick
(vi) R Kornberg

Column A	Column B
(1) Lac Operon	————–
(2) Central dogma in retroviruses	————-
(3) Coined the term Genome	————–
(4) Coined the term Genomics	————-
(5) Enzymatic synthesis of RNA	————-
(6) DNA is associated with histones and non-histones	————–

Column I [Phases]	Column II [Hormonal changes]
(1) Menstrual phase	(a) Rapid secretion of LH
(2) Proliferative phase	(b) Increased level of FSH and estrogen
(3) Ovulatory phase	(c) Increased level of progesterone
(4) Secretory phase	(d) Decrease in progesterone and estrogen