Question
A patient is suffering from ADA deficiency. Can he be cured? How?

Answer

A person suffering from ADA deficiency can be cured by various methods which are discusses below:
  • Bone Marrow Transplantation: This is a costly and risky surgical procedure. It requires a suitable donor which is difficult to find. An identical twin is supposed to be the best donor; because chances of tissue rejection are very high in bone marrow transplantation.
  • Enzyme Replacement Therapy: Enzyme replacement therapy is based on administering the missing enzyme to the patient by injection. This involves recurrent treatment that has escalated the cost this therapy.
  • Gene Therapy: Gene therapy involves taking out the lymphocytes from the patient’s blood. Then are lymphocytes are genetically engineered to add the missing gene. Recombinant lymphocytes are grown in suitable medium and then administered to the patient. This too is not a permanent cure because lymphocytes have a certain lifespan. The patient needs to be administered lymphocytes after frequent intervals. However, the gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stage could be permanent cure for this disease.

Need a full question paper?

Generate a complete, print-ready paper with questions like this in minutes — across 16+ boards, with answer keys.

Start Generating Free

Similar questions

Column A (Scientist)Column B (Theory)
(1) Munch(a) Proton transport theory
(2) Bohem(b) Pressure flow theory
(3) J. Pristley(c) Capillary theory
(4) Levitt(d) Root Pressure theory
Natality and Mortality.
Column AColumn B
(1) Frederick Griffith(a) Test tube assay
(2) Avery, McCarty and MacLeod(b) Streptococcus pneumoniae
(3) Alfred Hershey and Martha Chase(c) E. coli
(4) Meselson and Stahl(d) Bacteriophages
Distinguish between : Natural ecosystem and artificial ecosystem.
Read the following and answer any four questions from (i) to (v) given below:
X and Y are communicable diseases, whereas Wand Z are non-communicable diseases.X is transmitted through vectors whereas Y is transmitted through droplet infection. Wis caused due to a hormone deficiency, whereas Z is a degenerative disease. Based on the above information, answer the following questions.
  1. Identify W, X, Y and Z.
 
W
X
Y
Z
(a)
Coronary artery disease
Cholera
Chikungunya
Chikungunya
(b)
Diabetes
Malaria
Rhinitis
Alzheimer's disease
(c)
Alzheimer's disease
AIDS
Shigella
Plague
(d)
Gonorrhea
Diphtheria
Pertussis
Anthrax
  1. Select the correct statement.
  1. If X is sleeping sickness then its vector is Leishrnania.
  2. If Y is diphtheria then it is caused by Bacillus anthracis.
  3. If W is hypothyroidism then it is caused by deficiency of thyroxine hormone.
  4. If Z is myocardial infarction then patient develops acute rheumatic fever, joint pain and throat infection.
  1. If X and Y both are usual diseases then which of the following holds true?
  1. X could be dengue caused by flavivirus and Y could be AIDS caused by HIV.
  2. X could be chikungunya whereas Y could be rhinitis.
  3. X could be hepatitis whereas Y could be rabies.
  4. X could be chicken pox caused by Va rice/la zoster virus whereas Y could be yellow fever caused by flavivirus
  1. If X and Y both are bacterial diseases then select the correct match from the following.
  1. X- Bubonic plague-Yersinia pestis
  2. Y-Leprosy- Mycobacteriurn leprae
  3. X-Whooping cough-Bordetella pertussis
  4. Y-Botulism-Clostridiurn botulinum
  1. Assertion: Communicable diseases could be contagious or non-contagious.
Reason: Diseases that spread through vectors are non-contagious disease.
  1. Both assertion and reason are true, and reason is the correct explanation of assertion.
  2. Both assertion and reason are true, but reason is not the correct explanation of assertion.
  3. Assertion is true, but reason is false.
  4. Both assertion and reason are false.
Read the following and answer any four questions from (i) to (v) given below:
Many adaptations are found in flowers to achieve certain kind of pollination. The pollination achieved by insects is known as entomophily. The given diagram shows the cross-section of an anther of an insect pollinated flower.
  1. Which of the following is/ are the function(s) of structure Y?
  1. To carry waste products away from the anther.
  2. To supply oxygen to the cells of the anther.
  3. To transport food and mineral salts to the anther.
  4. To supply water to the anther.
  1. Conly.
  2. C and D only.
  3. A, B and D only.
  4. A, B, C and D.
  1. Which of the following most accurately describes the structures found in compartment X?
  1. They contain two haploid nuclei resulting from meiosis.
  2. They contain two haploid nuclei resulting from mitosis.
  3. They contain two haploid male gametes, resulting from mitosis.
  4. They contain a vegetative nucleus and pollen tube nucleus.
  1. Which of the following is a distinctive characteristic of insect-pollinated flower?
  1. All of them have nectar guides on their flowers.
  2. They produce sugary fruit.
  3. Their pollen grains tend to have rough surfaces.
  4. They produce abundant quantities of pollen to make up for pollen grains that might be removed by the wind.
  1. Which of the following are likely characteristics of the structures found in X and stamens of this plant?
S. No
Structure of X
Stamens
(a)
Abundant and light
Pendulous
(b)
Rough surfaces
Non-pendulous
(c)
Light and sticky
Pendulous
(d)
Coarse and sticky
Protrude outside the flower
  1. Spiny or sticky pollen grains and large, attractively coloured flowers are associated with:
  1. Hydrophily.
  2. Entomophily.
  3. Ornithophily.
  4. Anemophily.
Column A (Adaptation)Column B (Type of pollination)
(1) Sticky, spiny pollen grains non-fragrant flowers(a) Anemophily
(2) Feathery stigma and versatile anther(b) Chiropterophily
(3) Presence of nectar glands and sweet smell(c) Ornithophily
(4) Dull coloured flowers with strong fragrance(d) Entomophily
Read the following and answer any four questions from (i) to (v) given below:
Aditya went to his hometown located in countryside along with his parents during his summer vacations. His grand parents' house is surrounded by farmland from all sides. Lots of crops were growing nearby and Aditya was very excited to visit the crop fields. He seeked permission from his mother to play in farmland along with his friends and then went to play in the fields. On returning back he had running nose, watering eyes and continuous sneezing which was very frequent. TI1e symptoms worsened with time. Based on the above information, answer the following questions.
  1. What could be the possible reason for Aditya's condition?
  1. Allergy
  2. Infection
  3. Malnutrition
  4. Genetic disorder
  1. How can allergy be diagnosed in a person?
  1. Presence of large amount of IgE antibodies in the blood.
  2. Presence of large number of bacteria in the blood.
  3. Presence of bilirubin and bilirubin pigments in the stool.
  4. Presence of sickle shaped RBCs in the blood
  1. The symptoms which Aditya developed on account of being allergic are consequence of?
  1. Inflammation of membrane lining the nose and conjunctiva
  2. Swelling up of tissue surrounding bronchioles of lungs
  3. Dilation of all arteries so that large amount of fluid passes from blood to tissues.
  4. All of these.
  1. Name the type of allergy that Aditya developed.
  1. Asthma
  2. Anaphylaxis
  3. Hay fever
  4. Urticaria
  1. Assertion : Hay fever is the form of allergy due to pollens of grasses and other plants.
Reason : Hay fever symptoms are due to release of histamines and often respond well to treatment with antihistamines.
  1. Both assertion and reason are true, and reason is the correct explanation of assertion.
  2. Both assertion and reason are true, but reason is not the correct explanation of assertion.
  3. Assertion is true, but reason is false.
  4. Both assertion and reason are false.
Read the following and answer any four questions from $2(i)$ to $2(v)$ given below: Restriction endonuclease was isolated for the first ti me by W. Arb er in $1962$ in bacteria. Restriction endonucleases cut the DNA duplex at specific points therefore they are also called as molecular scissors or biological scissors. Three types of restriction endonucleases are Type I, Type II and Type III but only Type II restriction endonucleases are used in recombinant DNA technology. Restriction endonuclease EcoR I recognises the base sequence GAATTC in DNA duplex and cut strands between G and A.
  1. Only type II restriction enzymes are used in gene manipulation because
  1. ATP is not required for cleaving.
  2. It consists of three different subunits.
  3. It makes cleavage or cut in both the strands of DNA molecule.
  4. Both (a) and (c).
  1. Which of the following ions are used by restriction endonucleases for restriction?
  1. $Mg^{2+}$ ions
  2. $Mn^{2+}$​​​​​​​ ions
  3. $Na^{2+}$​​​​​​​ ions
  4. $K^{2+}$​​​​​​​ ions
  1. Restriction endonuclease was isolated for the first time in a:
  1. Plant cell.
  2. Animal cell.
  3. Prokaryotic cell.
  4. Genninal cell.
  1. Restriction endonucleases are also called as molecular or biological scissors because,
  1. They cleave base pairs of DNA only at their terminal ends.
  2. They cleave one or both the strands of DNA.
  3. They act only on single stranded DNA.
  4. None of these.
  1. Select the option that correctly states the working action of restriction endonuclease EcoR I on DNA sequence GAATTC
  1. $\ \ \ \ \ \ \ \ \ \ \ \ \downarrow\\5'-\text{GAATTC}-3'\\3'-\text{CTTAAG}-5'\\\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \uparrow$
  2. $ \ \ \ \ \ \ \ \ \ \ \downarrow\\5'-\text{GAATTC}-3'\\3'-\text{CTTAAG}-5'\\\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \uparrow$
  3. $\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \downarrow\\5'-\text{GAATTC}-3'\\3'-\text{CTTAAG}-5'\\\ \ \ \ \ \ \ \ \ \uparrow$
  4. $\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \downarrow\\5'-\text{GAATTC}-3'\\3'-\text{CTTAAG}-5'\\\ \ \ \ \ \ \ \ \ \ \ \ \ \ \uparrow$
Distinguish Between: Monohybrid cross and Dihybrid cross.