Question
Explain the difference between the forward strand and lagging strand of DNA.
✓
Answer
Differences between the Leading Strand and Lagging Strand :
| Leading Strand | Lagging Strand |
| 1. It is a replicated strand of DNA which grows continuously without any gap. | 1. Lagging strand is a replicated strand of DNA which is formed in short segments called Okazaki, fragments. Its growth is discontinuous. |
| 2. It does not require DNA ligase for its growth. | 2. DNA-ligase is required for joining Okazaki fragments. |
| 3. The direction of growth of the leading strand is $5^{\prime} \rightarrow 3^{\prime}$. | 3. The direction of growth of the lagging strand is $3^{\prime} \rightarrow 5^{\prime}$ though in each Okazaki fragment it is $5^{\prime} \rightarrow 3^{\prime}$. |
| 4. Only a single RNA primer is required. | 4. Starting of each Okazaki fragment requires a new RNA primer. |
| 5. Formation of leading strand is quite rapid. | 5. Formation of lagging strand is slower. |
| 6. Its template opens in $3^{\prime} \rightarrow 5^{\prime}$ direction. | 6. Its template opens in $5^{\prime} \rightarrow 3^{\prime}$ direction. |
| 7. Formation of leading strand begins immediately at the beginning of replication. | 7. Formation of lagging strand begins a bit later than that of leading strand. |
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